Platelet-rich plasma (PRP) is a regenerative medicine tactic that is commencing to gain momentum in the clinical setting. Platelet-Rich Plasma (PRP) is essentially a concentration of platelets isolated from one’s blood sample. Growth factors are an important part of the bioactive protein present in the sample, which plays an important role in tissue rejuvenation and is also known to speed up the healing cascade.

 

Wound Healing 

Wound healing is an intricate and dynamic procedure. When a wound commences healing, usually the process resolves with wound closure. Nevertheless, the healing of an acute and chronic wound can be affected by various factors such as comorbidities or infection.

Chronic and acute wounds are characterized by an extensive inflammatory phase that hampers wound healing; thus, platelet-rich plasma (PRP) is a progressive wound therapy solution. ( ). Platelet-rich plasma has been used to rouse wound healing as it consists of

  • Cytokines
  • Growth factors
  • Chemokines
  • A fibrin scaffold derivative from the patient’s blood.

A study conducted by Frykberg et al., states that 97% of the wounds responded to reduction in area and volume via platelet-rich plasma (PRP) therapy. The method of action for platelet-rich plasma is allegedly the molecular and cellular induction of standard wound-healing responses analogous to that observed with platelet activation. ()

 

PRP is a secure treatment option with no side effects, such as a bigger risk of infection or inflammation reactions. Concerning oncogenic probable, when likely coincidences between carcinogenesis and the mitogenic pathways employed by growth factors were assessed, no indication supports a conceivable tumoral triggering. ()

 

Bone Regeneration

Restoring the lost bone is of chief concern in disorders and settings concerning bone loss, including periodontitis, fractures, tumors, and bony defects. Autogenous bone is a solution to this but it comes with a number of set problems such as

 

  • Donor site morbidity
  • Trouble in obtaining the bone
  • Long healing time
  • Risk of disease transmission
  • Foreign body immune response

 

Platelet-rich plasma therapy has been observed to kindle osteoblast (cells that form new bone) propagation in vitro and to augment bone repair, apparently because of the high levels of autologous growth factors (). Apart from growth factors, it also contains- cytokines, enzymes, proteins, and fibrinolytic and anti-fibrinolytic proteins which are released upon the stimulation of the platelets via a mechanical or chemical pathway. Growth Factors like platelet-derived growth factor (PDGF), Transforming growth factor (TGF), and Insulin-like growth factor (IGF) are related to bone regeneration and development as they consist of proteins that are recognized to be present in the cells during wound healing and are henceforth identified to mimic bone healing environments (https://go.nature.com/2VfZPad). The application of PRP has exclusive benefits in the regeneration of bone such as accessibility, ease of isolation, good handling, and storage characteristics also, it eradicates the risk of disease transmission and immune rejection.

 

At Advancells, a PRP session is implemented in a very smooth and fairly easy manner; not devoting more than an hour for the completion.

30 ml of blood is drawn from one of the forearms and is transported into a sterile tube to prevent clotting. The Platelet Rich fraction is processed and enriched in a controlled atmosphere that is clinically permitted by reputed regulatory authorities. Prepared PRP serum is then infused back at the location of the injury, in amalgamation with stem cells to permit faster recovery.

If you are looking for a free consultation on wound healing or bone regenerative PRP treatment in India, contact [email protected]